Antimalarial Drugs
Antimalarial Drugs
Antimalarial drugs are APIs designed to prevent and treat malaria caused by Plasmodium species. These agents include quinoline derivatives, artemisinin-based therapies, antifolate combinations, and mitochondrial inhibitors that act on different stages of the parasite lifecycle. Their mechanisms involve disrupting heme detoxification, inhibiting folate metabolism, generating oxidative stress, or blocking electron transport chains. Antimalarial APIs are critical for treating acute malaria, preventing relapse in P. vivax and P. ovale infections, and supporting mass elimination programs. They are available as tablets, injectables, and fixed-dose combinations. With increasing global resistance, new antimalarial compounds remain a high priority in global health.
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