Description

Cycloguanil Hydrochloride is a potent dihydrofolate reductase (DHFR) inhibitor, serving as the primary active metabolite of the antimalarial proguanil. Its value lies in its targeted mechanism of action, which disrupts folate synthesis in susceptible parasites. This compound is essential for researchers and manufacturers in the pharmaceutical and life sciences sectors, particularly for developing and testing antimalarial therapies and studying drug resistance mechanisms.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of antimalarial drugs, specifically those related to the proguanil class.
• Biochemical Research: Used as a selective DHFR inhibitor in enzymatic studies and parasite biology research.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Mechanism of Action Studies: Employed to investigate parasite resistance patterns and the efficacy of antifolate compounds.
• Antiparasitic Agent Development: A key compound for screening and developing new therapeutic agents against protozoan infections.

Basic Information

Product Name	Cycloguanil Hydrochloride
CAS No.	152-53-4
Molecular Formula	C11H15Cl2N5
Molecular Weight	288.18 g/mol
Synonyms	Cycloguanil HCl; 1-(4-Chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine hydrochloride; Chloroguanide triazine metabolite; WR 38839; NSC 32968; 4,6-Diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine hydrochloride
EINECS	205-806-3

Quality Control

Our Cycloguanil Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.