Description

Hydroxychloroquine CAS NO 118-42-3 is a 4-aminoquinoline derivative and a critical active pharmaceutical ingredient (API) with significant therapeutic importance. This compound is valued for its immunomodulatory and antimalarial properties, making it a cornerstone in pharmaceutical manufacturing. It is primarily required by the pharmaceutical industry for the formulation of prescription medications used in the treatment of autoimmune diseases and malaria prophylaxis.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription drugs for treating autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematosus (SLE).
• Antimalarial Agent: Used in the prophylaxis and treatment of malaria, particularly in regions with chloroquine-sensitive strains.
• Research Chemical: Serves as a key reference standard and biochemical tool in immunological and parasitological research laboratories.
• Drug Formulation: Incorporated into various oral dosage forms, including tablets and capsules, under strict Good Manufacturing Practice (GMP) guidelines.
• Clinical Supply: Supplied to clinical trial organizations for investigational new drug (IND) applications and therapeutic studies.

Basic Information

Product Name	Hydroxychloroquine
CAS No.	118-42-3
Molecular Formula	C₁₈H₂₆ClN₃O
Molecular Weight	335.87 g/mol
Synonyms	Hydroxychloroquine Sulfate (common salt form); HCQ; Oxychloroquine; 2-[[4-[(7-Chloro-4-quinolyl)amino]pentyl]ethylamino]ethanol; Plaquenil (brand name); Ercoquin; Quensyl; IUPAC: (RS)-2-{[4-[(7-Chloro-4-quinoly)amino]pentyl](ethyl)amino}ethanol
EINECS	204-248-7

Quality Control

Our Hydroxychloroquine is manufactured and tested to meet stringent pharmacopeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing for identity, purity, and potency. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and heavy metals is provided to ensure full traceability and compliance with cGMP requirements for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability and prevent contamination.

Specification

Item	Specification
Appearance	White to almost white, crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Chloroquine	≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.