Description

(2S,3S,4R,5R)-N-(4-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)BUTYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-CARBOXAMIDE is a highly specialized, multi-functional nucleoside analog derivative characterized by its complex stereochemistry and multiple azido functional groups. This compound serves as a critical advanced intermediate in the synthesis of novel pharmaceutical agents, particularly in antiviral and anticancer research. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Bioconjugation & Click Chemistry: The multiple azido groups enable efficient, site-specific conjugation with alkyne-functionalized molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Proteomics & Chemical Biology: Used as a probe or tag in activity-based protein profiling (ABPP) and target identification studies.
• Glycobiology Research: Serves as a sophisticated precursor for synthesizing complex, modified carbohydrate analogs for studying biological recognition processes.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies to optimize the potency and selectivity of therapeutic leads.
• Precision Synthesis: Employed in the development of stereochemically defined oligonucleotide analogs and other bioactive molecules.

Basic Information

Item	Details
Product Name	(2S,3S,4R,5R)-N-(4-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)BUTYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-CARBOXAMIDE
CAS No.	948916-18-5
Molecular Formula	C26H38N16O12
Molecular Weight	734.68 g/mol
Synonyms	Azido-functionalized Nucleoside Derivative; Multi-azido Uridine Analog; Click Chemistry Nucleoside Intermediate; CAS 948916-18-5; 1-(4-((2S,3S,4R,5R)-5-((4-((1S,2S,3S,5R,6R)-3,5-Diazido-2-((2S,3R,4R,5S,6R)-3-azido-6-(azidomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yloxy)-6-hydroxycyclohexylamino)butyl)carbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; Complex Azido Nucleoside
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and structural integrity. Identity and purity are confirmed via advanced analytical techniques including HPLC, NMR, and Mass Spectrometry. Our quality system ensures compliance with research-grade and cGMP standards for advanced pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be kept in a dry, well-ventilated area away from heat sources and incompatible materials. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.