Description

D-Azidoalanine is a specialized non-proteinogenic amino acid derivative featuring an azido functional group, which serves as a versatile chemical handle for bioorthogonal click chemistry reactions. This compound is critical for researchers and manufacturers developing advanced bioconjugates, peptide-based therapeutics, and novel chemical probes. It is primarily utilized in pharmaceutical R&D, proteomics, and materials science for site-specific labeling and modification of biomolecules.

Application

• Peptide Synthesis & Modification: Used as a building block for incorporating clickable azide groups into synthetic peptides for subsequent conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Bioconjugation & Labeling: Enables site-specific attachment of fluorophores, drugs, or other payloads to proteins, antibodies, and other biologics for creating targeted therapeutics and diagnostic agents.
• Chemical Biology Probes: Serves as a metabolic precursor or chemical probe to study biological processes through bioorthogonal labeling strategies in live cells.
• Materials Science: Employed in the surface functionalization of polymers and nanoparticles to create bioactive interfaces for biomedical and sensor applications.
• Pharmaceutical Intermediate: Acts as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).

Basic Information

Product Name	D-Azidoalanine
CAS No.	105928-88-9
Molecular Formula	C3H6N4O2
Molecular Weight	130.10 g/mol
Synonyms	D-2-Azidoalanine; (R)-2-Azido-3-aminopropanoic acid; (R)-2-Azidoalanine; D-α-Azidoalanine; Azido-D-alanine; (2R)-2-Azidopropanoic acid; D-Azido-Ala-OH; D-N3Ala
EINECS	Contact for details

Quality Control

Our D-Azidoalanine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic and should be handled under an inert atmosphere to maintain stability. Keep away from strong acids and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.