Description

F26 Fmoc-Cl, Chlorameisens?:ure-[1,8-bis-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluornonyl)-9-fluorenyl]-methyl-ester, [1,8-Bis(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyl)-9-fluorenyl]methyl chloroformate is a highly fluorinated derivative of the classic Fmoc-chloroformate reagent, designed for specialized peptide synthesis and organic transformations. This compound matters for its unique combination of extreme lipophilicity and fluorophilicity, enabling applications in challenging environments where standard reagents fail. It is primarily needed by researchers and process chemists in pharmaceutical development, advanced materials science, and specialty chemical synthesis, particularly for modifying peptides and creating fluorinated molecular architectures.

Application

• Fluorous-Phase Peptide Synthesis (FPS): As a fluorinated Fmoc-protecting group reagent for the selective introduction and subsequent purification of peptides using fluorous solid-phase extraction (F-SPE).
• Synthesis of Fluorinated Biomolecules: For the selective protection of amines in the preparation of perfluorinated analogs of peptides, sugars, or other bioactive molecules to alter their pharmacokinetic properties.
• Advanced Materials Research: As a building block for creating novel fluorinated polymers, dendrimers, or surface modifiers with unique hydrophobic and oleophobic characteristics.
• Catalyst and Ligand Development: In the synthesis of fluorinated ligands for catalysis in biphasic or supercritical CO2 systems, leveraging its solubility in fluorinated solvents.
• Proteomics and Chemical Biology: As a specialized tagging or cross-linking reagent for studying protein-protein interactions or creating activity-based probes with enhanced membrane permeability.
• High-Throughput Screening (HTS) Library Synthesis: Enabling the parallel synthesis of compound libraries that are easily separable via fluorous tagging strategies.

Basic Information

Product Name	F26 Fmoc-Cl, Chlorameisens?:ure-[1,8-bis-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluornonyl)-9-fluorenyl]-methyl-ester, [1,8-Bis(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyl)-9-fluorenyl]methyl chloroformate
CAS No.	932710-57-1
Molecular Formula	C31H10ClF26O3
Molecular Weight	~956.73 g/mol (Contact for details)
Synonyms	[1,8-Bis(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyl)-9-fluorenyl]methyl chloroformate; F26-Fmoc-Cl; Fmoc-Cl (F26 analog); Perfluorinated Fmoc-Chloroformate; 9-Fluorenylmethyl N-([1,8-bis(perfluorononyl)]-9-fluorenyl) chloroformate; Heavily Fluorinated Fmoc Protecting Reagent; Fluorous Fmoc Chloroformate
EINECS	Contact for details

Quality Control

Our F26 Fmoc-Cl is produced under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation. Certificates of Analysis (COA) detailing specific lot results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.