Description

Acetoxyacetyl Chloride is a highly reactive acyl chloride derivative, primarily used as a versatile building block in organic synthesis. Its core value lies in its ability to efficiently introduce the acetoxyacetyl functional group, enabling the synthesis of complex molecules with high atom economy. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it serves as a key intermediate for creating active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of β-lactam antibiotics and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators.
• Polymer Chemistry: Acts as a monomer or modifying agent for specialty polymers and coatings.
• Peptide Synthesis: Employed as an acylating agent for the protection of amino groups or modification of peptide chains.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of complex organic dyes and colorants.
• Cross-coupling Reactions: Serves as a substrate in palladium-catalyzed reactions for carbon-carbon bond formation.

Basic Information

Product Name	Acetoxyacetyl Chloride
CAS No.	13831-31-7
Molecular Formula	C4H5ClO3
Molecular Weight	136.53 g/mol
Synonyms	Acetoxyacetyl chloride; Acetyloxyacetyl chloride; 2-Acetoxyacetyl chloride; Acetic acid, 2-chloro-2-oxoethyl ester; Chloroacetic acid acetate; Glycolic acid acetate chloride; 2-(Chloroformyloxy)acetone (incorrect but sometimes used); Acetyl glycolyl chloride
EINECS	237-558-5

Quality Control

Our Acetoxyacetyl Chloride is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to minimize decomposition and volatility. Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Acidity (Titration)	≤ 1.0% (as acetic acid)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.