Description

(S)-(-)-2-Acetoxypropionyl Chloride is a high-purity chiral building block and an activated ester derivative. This compound is a critical intermediate for the synthesis of enantiomerically pure pharmaceuticals and advanced agrochemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for introducing the (S)-2-acetoxypropionyl moiety into target molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of active pharmaceutical ingredients (APIs), particularly in antibiotic and antiviral drug development.
• Asymmetric Synthesis: Used in stereoselective acylation reactions to construct complex molecules with high enantiomeric excess.
• Peptide & Prodrug Chemistry: Serves as an acylating agent for modifying amino acids or creating prodrug forms to enhance bioavailability.
• Agrochemical Research: Intermediate in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Material Science: Potential monomer or modifier for creating specialized polymers with specific optical or mechanical properties.
• Academic & Contract Research: Valuable reagent for methodological development in organic chemistry and catalysis studies.

Basic Information

Product Name	(S)-(-)-2-Acetoxypropionyl Chloride
CAS No.	36394-75-9
Molecular Formula	C5H7ClO3
Molecular Weight	150.56 g/mol
Synonyms	(S)-2-Acetoxypropionyl Chloride; (S)-(-)-2-Acetoxypropanoic Acid Chloride; (S)-2-Acetoxypropanoic Acid Chloride; (S)-α-Acetoxypropionyl Chloride; L-2-Acetoxypropionyl Chloride; (S)-2-Acetoxypropionyl Chloride; (S)-O-Acetyllactoyl Chloride; (2S)-2-Acetoxypropanoyl Chloride
EINECS	Contact for details

Quality Control

Our (S)-(-)-2-Acetoxypropionyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data, including enantiomeric excess (ee), are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C. Due to its properties as a strong acid/organic solvent, hygroscopic (moisture-sensitive), and highly volatile nature, it must be kept under an inert atmosphere (e.g., nitrogen or argon) and handled in a controlled environment to prevent hydrolysis and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.