Description

Methyl Malonyl Chloride is a highly reactive acid chloride derivative of malonic acid, serving as a crucial building block in organic synthesis. Its primary value lies in its ability to efficiently introduce the methyl malonyl moiety, enabling the construction of complex molecular frameworks. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to synthesize active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of compounds with complex carboxylic acid derivatives.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require specific malonate-based structures.
• Peptide Mimetics & Conjugation: Facilitates the introduction of the methyl malonyl group into peptide chains or biomolecules for drug discovery and bioconjugation applications.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers and functional materials.
• Organic Synthesis Reagent: Employed in various name reactions and coupling procedures to form carbon-carbon bonds and introduce functional groups.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating novel chemical entities.

Basic Information

Product Name	Methyl Malonyl Chloride
CAS No.	37517-81-0
Molecular Formula	C4H5ClO3
Molecular Weight	136.53 g/mol
Synonyms	Monomethyl malonyl chloride; Methylmalonyl chloride; Methyl propanedioyl chloride; 2-Methoxyoxalyl chloride; Methylmalonic acid chloride; Propanedioic acid, methyl-, chloride; Chlorocarbonylacetic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl Malonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets high-grade specifications suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to maximize stability. Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.