Description

(1R,4R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis(tert-butyldimethylsilyloxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol is a sophisticated, high-purity synthetic intermediate characterized by its complex stereochemistry and functional groups. This compound is of significant value in advanced organic synthesis, particularly for constructing intricate molecular architectures found in active pharmaceutical ingredients (APIs) and novel materials. It is primarily sought after by research institutions and pharmaceutical development teams engaged in the synthesis of complex therapeutic agents, including vitamin D analogs and other steroidal frameworks.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a critical building block in the multi-step synthesis of complex drug candidates, especially those with vitamin D-related activity.
• Steroid and Secosteroid Research: Used in academic and industrial research laboratories for the development and study of novel steroid and secosteroid derivatives.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of high-value target molecules.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study biological pathways and receptor interactions.
• Advanced Material Precursors: Potential use as a precursor for synthesizing specialized organic materials with specific optical or electronic properties.

Basic Information

Product Name	(1R,4R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis(tert-butyldimethylsilyloxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol
CAS No.	910133-34-5
Molecular Formula	C41H72O3Si2
Molecular Weight	669.2 g/mol
Synonyms	1-Cyclopropyl-4-[(1R,3aS,7aR)-4-[(1E)-2-[(1E,3S,5R)-3,5-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-1,2,3,3a,5,6,7,7a-octahydro-1H-inden-1-yl]-(2E)-2-penten-1-ol; (1R,4R,E)-1-Cyclopropyl-4-[(1R,3aS,7aR,E)-4-[(E)-2-[(3S,5R)-3,5-Bis(tert-butyldimethylsiloxy)-2-methylidenecyclohexylidene]ethylidene]-7a-methyloctahydro-1H-inden-1-yl]pent-2-en-1-ol; TBS-protected Vitamin D intermediate; Steroidal TBS ether intermediate; Secosteroid synthesis intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, essential for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, stereochemical purity, and impurity profile. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Diastereomeric Purity	≥ 99.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.