Description

Tris(Trimethylsilyl)Phosphite is a versatile organosilicon reagent primarily used as a silylating agent and a phosphorus source in organic synthesis. Its value lies in its ability to protect hydroxyl groups and introduce phosphite functionalities under mild conditions, enabling the synthesis of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for process development and production.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent in the preparation of nucleoside phosphonates and other active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used as a building block for synthesizing novel pesticides and herbicides.
• Polymer & Material Science: Acts as a monomer or additive in the creation of flame-retardant and specialty polymers.
• Silicon Chemistry: Serves as a trimethylsilyl donor for protecting sensitive functional groups during multi-step syntheses.
• Ligand & Catalyst Preparation: Employed in the synthesis of phosphite-based ligands for asymmetric catalysis.
• Laboratory Research: A valuable tool for academic and industrial R&D in organic and organometallic chemistry.

Basic Information

Product Name	Tris(Trimethylsilyl)Phosphite
CAS No.	1795-31-9
Molecular Formula	C9H27O3P Si3
Molecular Weight	298.55 g/mol
Synonyms	Phosphorous Acid Tris(trimethylsilyl) Ester; Tris(O-trimethylsilyl) Phosphite; Trimethylsilyl Phosphite; Tris(trimethylsilyl) Phosphite; Tris(trimethylsiloxy)phosphine; P(O-SiMe3)3; TTSP
EINECS	217-277-8

Quality Control

Our Tris(Trimethylsilyl)Phosphite is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.