Description

N-Trimethylsilylbenzamide is a versatile organosilicon reagent primarily used as a silylating agent and a key synthetic intermediate. Its value lies in its ability to protect reactive functional groups and facilitate the synthesis of complex molecules in high-purity environments. This compound is essential for research and production in the pharmaceutical, agrochemical, and advanced materials sectors, where precise chemical modification is critical.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly in protecting group chemistry during multi-step organic synthesis.
• Silylating Agent: Protects hydroxyl and amine groups in sensitive reactions, enabling selective transformations in complex molecule assembly.
• Agrochemical Synthesis: Serves as a building block for creating advanced crop protection agents and herbicides.
• Organic Synthesis Reagent: A valuable tool in academic and industrial R&D labs for constructing novel organic compounds and heterocycles.
• Silicon-Based Material Precursor: Used in the development of specialty silicones and silicon-containing polymers.
• Chemical Derivatization: Employed in analytical chemistry for modifying compounds to enhance their detectability in techniques like gas chromatography (GC) or mass spectrometry (MS).

Basic Information

Product Name	N-Trimethylsilylbenzamide
CAS No.	1011-57-0
Molecular Formula	C10H15NOSi
Molecular Weight	193.32 g/mol
Synonyms	Benzamide, N-(trimethylsilyl)-; N-(Trimethylsilyl)benzamide; Trimethylsilyl benzamide; Benzamide, N-trimethylsilyl-; TMS-Benzamide; N-TMS-Benzamide; N-(Trimethylsilyl)benzenecarboxamide; 1-(Trimethylsilyl)-1H-benzimidazole (Note: This is a common mis-association; the correct structure is benzamide-based)
EINECS	213-789-8

Quality Control

Our N-Trimethylsilylbenzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.