Description

Phenol, 2-[(Trimethylsilyl)ethynyl]- is a specialized organosilicon intermediate featuring a phenolic hydroxyl group and a protected acetylene moiety. This unique bifunctional structure makes it a valuable building block for synthesizing complex molecules in advanced material and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring acetylene or phenolic coupling reactions.
• Material Science Research: Building block for novel polymers, dendrimers, and liquid crystals, where the silyl-protected alkyne allows for controlled polymerization or cross-linking.
• Organic Synthesis Reagent: Used in Sonogashira coupling and other palladium-catalyzed cross-coupling reactions to introduce phenolic acetylene units into target molecules.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands for metal catalysis or organocatalysts.
• Agrochemical Synthesis: Intermediate in the development of new crop protection agents and herbicides with tailored properties.
• Academic & Industrial R&D: Fundamental research tool in synthetic organic chemistry for exploring new reaction pathways and molecular scaffolds.

Basic Information

Product Name	Phenol, 2-[(Trimethylsilyl)ethynyl]-
CAS No.	81787-62-4
Molecular Formula	C11H14OSi
Molecular Weight	190.31 g/mol
Synonyms	2-[(Trimethylsilyl)ethynyl]phenol; 2-(Trimethylsilylethynyl)phenol; 2-Ethynylphenol trimethylsilyl ether; o-(Trimethylsilylethynyl)phenol; Phenol, o-[(trimethylsilyl)ethynyl]-; TMS-ethynylphenol; 2-Hydroxyphenyl(trimethylsilyl)acetylene
EINECS	Contact for details

Quality Control

Our production of Phenol, 2-[(Trimethylsilyl)ethynyl]- adheres to strict internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by modern analytical techniques including NMR, HPLC, and GC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.