Description

(2R,6S,12Z,13aS,14aR,16aS)-6-[[(Cyclopentyloxy)carbonyl]amino]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[2-[(1-methylethyl)amino]-4-thiazolyl]-4-quinolinyl]oxy]-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylic acid is a complex, high-purity macrocyclic compound designed for advanced research and development applications. This molecule is of significant interest due to its sophisticated structure, which incorporates multiple pharmacologically relevant motifs, making it a valuable intermediate or reference standard in pharmaceutical discovery. It is primarily utilized by research institutions, biotechnology firms, and pharmaceutical companies engaged in the synthesis and screening of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or building block in the synthesis of novel drug candidates, particularly in oncology and infectious disease research.
• Chemical Biology Studies: Used as a probe or tool compound to investigate specific biological pathways and protein interactions due to its complex, target-oriented structure.
• Analytical Reference Standard: Employed as a high-purity standard in analytical method development and validation for quality control (QC) and quality assurance (QA) in API manufacturing.
• Process Chemistry Optimization: Utilized in scaling up and optimizing synthetic routes for complex macrocyclic molecules in pilot plant and manufacturing settings.
• Academic Research: Supports cutting-edge academic studies in synthetic organic chemistry, medicinal chemistry, and pharmacology.

Basic Information

Product Name	(2R,6S,12Z,13aS,14aR,16aS)-6-[[(Cyclopentyloxy)carbonyl]amino]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[2-[(1-methylethyl)amino]-4-thiazolyl]-4-quinolinyl]oxy]-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylic acid
CAS No.	849022-30-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	849022-30-6; Telaprevir Impurity; Telaprevir Related Compound; Cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylic acid derivative; VX-950 Impurity; INCIVEK Impurity; INCIVO Impurity; Macrocyclic HCV Protease Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to confirm identity and purity. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.