Description

Lestaurtinib is a potent and selective small-molecule inhibitor of multiple receptor tyrosine kinases, most notably FLT3 (FMS-like tyrosine kinase 3). This compound is of significant interest in pharmaceutical research and development for its targeted therapeutic potential. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and preclinical studies, particularly for the investigation of acute myeloid leukemia (AML) and other hematologic malignancies.

Application

• Oncology Research: A key investigational agent for targeting FLT3 mutations in preclinical models of acute myeloid leukemia (AML).
• Kinase Profiling: Used as a selective biochemical tool to study the role of JAK2, TrkA, and other tyrosine kinases in cellular signaling pathways.
• Drug Discovery: Serves as a reference standard and lead compound in the development of novel targeted cancer therapies.
• Mechanistic Studies: Employed in vitro and in vivo to elucidate the mechanisms of drug resistance and to identify potential combination therapies.
• Biopharmaceutical R&D: Used in the formulation and stability testing of potential therapeutic candidates.

Basic Information

Product Name	Lestaurtinib
CAS No.	111358-88-4
Molecular Formula	C₂₆H₂₂F₂N₈O
Molecular Weight	500.51 g/mol
Synonyms	CEP-701; KT-5555; 3-(1H-Indol-3-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid (4-trifluoromethyl-phenyl)-amide; N-Benzyl-3-(1H-indol-3-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
EINECS	Contact for details

Quality Control

Our Lestaurtinib is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.