Description

Vorinostat CAS NO 149647-78-9 is a potent and selective inhibitor of histone deacetylases (HDACs), specifically Class I and II HDAC enzymes. This compound is a critical research tool and active pharmaceutical ingredient (API) for investigating epigenetic regulation and developing novel cancer therapeutics. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and contract manufacturing organizations (CMOs) focused on oncology drug discovery and development.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of finished dosage forms for clinical and commercial use.
• Oncology Research: A key reference standard and tool compound for studying histone deacetylase inhibition, gene expression, and apoptosis in cancer cell lines.
• Preclinical & Clinical Development: Used in the manufacturing of drug substances for non-clinical safety studies and clinical trials targeting various cancers.
• Biochemical Assay Development: Serves as a positive control in high-throughput screening (HTS) assays to identify and validate new HDAC inhibitors.
• Epigenetics Research: Fundamental for exploring chromatin remodeling, cellular differentiation, and other epigenetic mechanisms in disease models.

Basic Information

Product Name	Vorinostat
CAS No.	149647-78-9
Molecular Formula	C14H20N2O3
Molecular Weight	264.32 g/mol
Synonyms	Suberoylanilide hydroxamic acid (SAHA); MK-0683; Zolinza; N-Hydroxy-N'-phenyloctanediamide; L-001079038; HDAC inhibitor SAHA; NSC 701852; Merck 0683
EINECS	Contact for details

Quality Control

Our Vorinostat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength, meeting specifications suitable for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.