Description

2-Furyl-[4-[4-[[4-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Amino] -6,7-Dimethoxy-Quinazolin-2-Yl]Piperazin-1-Yl]Methanone Trihydrochloride is a high-purity, complex organic salt primarily used as a key pharmaceutical intermediate or reference standard in advanced research and development. This compound is critical for the synthesis and study of targeted therapeutic agents, particularly in oncology and signal transduction pathway research. It is essential for pharmaceutical manufacturers, biotechnology R&D laboratories, and academic institutions focused on developing novel kinase inhibitors and other specialized drug candidates.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of advanced active pharmaceutical ingredients (APIs), particularly for targeted cancer therapies.
• Kinase Inhibitor Research: Serves as a reference compound or precursor in the development and biological evaluation of novel quinazoline-based kinase inhibitors.
• Biochemical Assay Standard: Used as a high-purity standard in analytical methods (HPLC, LC-MS) for quality control and pharmacokinetic studies.
• Medicinal Chemistry R&D: A valuable scaffold for structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and metabolic stability.
• Preclinical Development: Employed in the formulation of drug candidates for in vitro and in vivo efficacy and toxicity testing.
• Contract Manufacturing (CMO): Supplied to CMOs engaged in the production of complex, small-molecule therapeutics under cGMP guidelines.

Basic Information

Product Name	2-Furyl-[4-[4-[[4-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Amino] -6,7-Dimethoxy-Quinazolin-2-Yl]Piperazin-1-Yl]Methanone Trihydrochloride
CAS No.	111218-85-0
Molecular Formula	C31H37Cl3N6O6
Molecular Weight	684.02 g/mol
Synonyms	2-Furyl(4-(4-((4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)amino)-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl)methanone trihydrochloride; N-[4-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl]-6,7-dimethoxy-4-[4-(2-furoyl)piperazin-1-yl]quinazolin-2-amine trihydrochloride; 2-Furoyl-piperazine-quinazoline derivative trihydrochloride; Kinase inhibitor intermediate trihydrochloride salt; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-Furyl-[4-[4-[[4-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Amino] -6,7-Dimethoxy-Quinazolin-2-Yl]Piperazin-1-Yl]Methanone Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC purity, NMR, and mass spectrometry for structural confirmation and identity. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing purity, impurities, and other critical parameters. Specifications can be aligned with research or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.