Description

Olaparib is a potent and selective small-molecule inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, specifically PARP-1, PARP-2, and PARP-3. This compound is a critical active pharmaceutical ingredient (API) used in targeted cancer therapy, exploiting the concept of synthetic lethality in tumors with homologous recombination deficiencies. It is essential for pharmaceutical manufacturers and research institutions developing and producing advanced oncology treatments. The high-purity material is vital for ensuring the efficacy and safety of the final drug product.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of finished dosage forms (e.g., tablets) for cancer treatment.
• Oncology Research: A key tool compound in preclinical and clinical research for studying PARP inhibition, DNA damage response, and mechanisms of synthetic lethality.
• Targeted Therapy Development: Used in R&D for developing new combination therapies and next-generation PARP inhibitors.
• Biomarker Studies: Employed in laboratories to investigate biomarkers associated with response to PARP inhibitor therapy, such as BRCA mutations.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in pharmaceutical labs.
• Formulation Development: Used in the development and optimization of drug delivery systems and formulations to enhance stability and bioavailability.

Basic Information

Product Name	Olaparib
CAS No.	763113-22-0
Molecular Formula	C24H23FN4O3
Molecular Weight	434.46 g/mol
Synonyms	AZD-2281; KU-0059436; Lynparza (trade name); 4-[[3-[4-(Cyclopropylcarbonyl)piperazin-1-yl]carbonyl]-4-fluorophenyl]methyl(2H)phthalazin-1-one; (3S)-3-(4-{[3-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one; PARP Inhibitor AZD2281; Olaparibum
EINECS	Contact for details

Quality Control

Our Olaparib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the highest standards for pharmaceutical use, including identity, purity, and impurity profile. We provide full traceability and support regulatory submissions. Certificates of Analysis (COA) are available upon request, detailing specifications and results from advanced techniques like HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.10%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.