Description

Midostaurin is a potent and selective small-molecule inhibitor of multiple protein kinases, including FLT3, KIT, and PKC. This compound is of critical importance in pharmaceutical research and development, particularly in the field of targeted oncology therapies. It is primarily needed by pharmaceutical manufacturers, advanced research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of novel therapeutics for acute myeloid leukemia (AML) and other malignancies.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of targeted cancer therapies.
• Biochemical Research as a key tool compound for studying FLT3 and KIT signaling pathways in hematological cancers.
• Preclinical Development for efficacy and safety studies in relevant animal models of AML and systemic mastocytosis.
• Reference Standard for quality control and analytical method development in pharmaceutical manufacturing.
• Process Chemistry for the development and scale-up of synthetic routes for kinase inhibitor production.

Basic Information

Product Name	Midostaurin
CAS No.	120685-11-2
Molecular Formula	C35H30N4O4
Molecular Weight	570.64 g/mol
Synonyms	PKC412; N-Benzoylstaurosporine; CGP 41251; 4'-N-Benzoylstaurosporine; (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one; Rydapt (brand name)
EINECS	Contact for details

Quality Control

Our Midostaurin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.