Description

[[[[(2R,3R,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid is a high-purity nucleotide triphosphate analog, specifically the triphosphate form of cytidine. This compound is a critical building block for life science research and pharmaceutical development, serving as a direct precursor for RNA synthesis and enzymatic reactions. It is essential for researchers and manufacturers in molecular biology, enzymology, and nucleotide-based therapeutics, where precise biochemical activity and structural integrity are paramount. Our supply ensures the quality and consistency required for sensitive applications.

Application

• Enzymatic RNA Synthesis: As a substrate for RNA polymerases (e.g., T7, SP6) in in vitro transcription for mRNA production, ribozyme studies, and probe generation.
• Biochemical Assay Development: Used in kinetic studies of RNA polymerases, helicases, and other nucleic acid-metabolizing enzymes to understand mechanism and inhibition.
• Nucleotide Metabolism Research: A key reagent for studying pathways involving cytidine triphosphate (CTP) utilization in cellular processes.
• Pharmaceutical Intermediate: Serves as a starting material or critical component in the synthesis of nucleotide-based antiviral drugs, antisense oligonucleotides, and other therapeutic agents.
• Diagnostic Kit Manufacturing: Incorporated into kits for nucleic acid amplification (PCR, isothermal amplification) and sequencing that require high-fidelity nucleotide mixes.
• Structural Biology Studies: Used in crystallography and NMR studies of protein-nucleic acid complexes to elucidate binding and catalytic mechanisms.

Basic Information

Item	Details
Product Name	[[[[(2R,3R,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
CAS No.	87980-19-6
Molecular Formula	C9H16N3O14P3
Molecular Weight	483.14 g/mol
Synonyms	Cytidine 5'-triphosphate (CTP); Cytidine triphosphate; 5'-CTP; Cytidine-5'-triphosphate; CTP trisodium salt (common salt form); 5'-O-({Hydroxy[(hydroxy{hydroxy[(hydroxyphosphinato)oxy]phosphoryl}oxy)phosphoryl]oxy}phosphoryl)cytidine; 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-({hydroxy[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)oxolan-2-yl]-4-aminopyrimidin-2-one
EINECS	Contact for details

Quality Control

Our Cytidine Triphosphate (CTP) is manufactured under strict quality systems to ensure it meets the exacting standards of research and pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity, NMR for structural confirmation, and stringent tests for endotoxins and nucleases. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, impurities, and biological activity where applicable. Production can adhere to GMP guidelines for advanced therapeutic applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis. For aliquot preparation, use dry, sterile conditions.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Anhydrous basis)
Water Content (KF)	≤ 5.0 %
pH (1% Solution)	6.0 - 7.5
Endotoxin	< 10 EU/mg (for applicable grades)
Bioburden	To meet customer specification

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.