Description

Methyl (19E,21E,23E,25E,27E,29E,31E)-33-[4-(2,6-diaminohexanoylamino)-3,5-dihydroxy-6-methyl-oxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate is a complex, high-purity macrolide derivative of significant interest in advanced pharmaceutical research and development. Its intricate structure, featuring multiple hydroxyl groups and a conjugated polyene system, makes it a valuable intermediate or reference standard for synthesizing novel bioactive compounds. This product is essential for R&D teams in the pharmaceutical and biotechnology sectors focused on developing new therapeutic agents, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel antibiotic or antifungal agents, leveraging its complex macrolactone core.
• Biochemical Research: Used as a high-purity reference standard or probe in studies investigating structure-activity relationships (SAR) of polyene macrolides.
• API Development: Acts as a key precursor in the research and process development stages for new Active Pharmaceutical Ingredients (APIs) with targeted biological activity.
• Academic Research: Employed in university and institutional laboratories for chemical biology studies and the exploration of new synthetic methodologies for complex natural product analogs.

Basic Information

Product Name	Methyl (19E,21E,23E,25E,27E,29E,31E)-33-[4-(2,6-diaminohexanoylamino)-3,5-dihydroxy-6-methyl-oxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate
CAS No.	76023-48-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Methyl 33-O-(4-(2,6-Diaminohexanoylamino)-3,5-dihydroxy-6-methyl-tetrahydropyran-2-yl)-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate; Amphotericin B Methyl Ester Derivative; Polyene Macrolide Methyl Ester; CAS 76023-48-8; (19E,21E,23E,25E,27E,29E,31E)-Isomer of Methyl Amphotericin Derivative
EINECS	Contact for details

Quality Control

Every batch of our methyl (19E,21E,23E,25E,27E,29E,31E)-33-[4-(2,6-diaminohexanoylamino)-3,5-dihydroxy-6-methyl-oxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate is manufactured and analyzed under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay purity and related substances.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.