Description

Oligomycin B CAS NO 11050-94-5 is a potent, macrocyclic polyketide antibiotic belonging to the oligomycin complex, primarily known as a specific inhibitor of mitochondrial ATP synthase (F0F1 ATPase). This compound is a critical research tool in biochemistry and cell biology for studying oxidative phosphorylation, cellular energy metabolism, and apoptosis. It is essential for researchers and manufacturers in the life sciences sector, particularly those focused on mitochondrial function, cancer research, and the development of metabolic pathway modulators.

Application

• Biochemical Research: Used as a specific inhibitor of the mitochondrial F0 subunit of ATP synthase to study oxidative phosphorylation, proton gradients, and cellular bioenergetics.
• Cell Biology & Cancer Research: Employed to investigate the role of mitochondrial metabolism in apoptosis, cancer cell proliferation, and tumorigenesis.
• Pharmacology & Toxicology: Serves as a reference standard and tool compound for screening and evaluating new therapeutic agents targeting mitochondrial function.
• Antifungal Research: Studied for its inherent antifungal properties against various yeast and fungal strains, aiding in the development of novel antifungal agents.
• Metabolic Disorder Studies: Applied in models to understand diseases linked to mitochondrial dysfunction, such as neurodegenerative disorders.
• Academic & Industrial R&D: A fundamental reagent for universities, contract research organizations (CROs), and pharmaceutical companies engaged in fundamental and applied life science research.

Basic Information

Product Name	Oligomycin B
CAS No.	11050-94-5
Molecular Formula	C45H74O11
Molecular Weight	791.1 g/mol
Synonyms	Oligomycin B; Oligomycin B complex; 28,34-Didehydrooligomycin A; Antibiotic 66-40B; NSC 131233; Oligomycin (from Streptomyces diastatochromogenes); F0F1-ATPase inhibitor; ATP synthase inhibitor
EINECS	Contact for details

Quality Control

Our Oligomycin B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA), documenting identity, purity, and other critical parameters, is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere to minimize oxidation and ensure long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Biological Activity	Inhibits mitochondrial ATP synthase (F0F1-ATPase)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.