Description

Amphotericin A CAS NO 1405-32-9 is a polyene macrolide antibiotic, closely related to the more widely known Amphotericin B. This compound is of significant interest in pharmaceutical research and development due to its antifungal properties. It serves as a critical reference standard and starting material for researchers and manufacturers in the life sciences sector, particularly for investigating antifungal mechanisms and developing novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in antifungal drug manufacturing.
• Biomedical Research: Employed in in vitro and in vivo studies to investigate the structure-activity relationships (SAR) of polyene antibiotics and their interaction with fungal cell membranes.
• Antifungal Agent Development: Serves as a lead compound or intermediate in the synthesis and development of new antifungal therapeutics with potentially improved efficacy or reduced toxicity profiles.
• Microbiological Studies: Utilized in laboratory settings to study fungal resistance mechanisms and to screen for synergistic effects with other antimicrobial compounds.
• Academic & Institutional Research: A key reagent for universities and research institutes focusing on microbiology, pharmacology, and medicinal chemistry.

Basic Information

Product Name	Amphotericin A
CAS No.	1405-32-9
Molecular Formula	C46H73NO17
Molecular Weight	924.1 g/mol
Synonyms	Amphotericin A; Amphotericin A1; 28,29-Didehydroamphotericin B; Fungilin A; Ampho A; NSC 527017; Antibiotic A 271; Polyene Antibiotic A 271
EINECS	Contact for details

Quality Control

Our Amphotericin A is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Specific Rotation	Contact for details
Biological Activity	Assayed (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.