Description

Amphotericin B CAS NO 1397-89-3 is a potent polyene macrolide antifungal antibiotic derived from *Streptomyces nodosus*. It is critically valued for its broad-spectrum fungicidal activity, primarily targeting ergosterol in fungal cell membranes. This makes it an essential active pharmaceutical ingredient (API) for the formulation of life-saving antifungal medications. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for severe systemic fungal infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable and topical antifungal formulations.
• Systemic Antifungal Therapy: Treatment of serious, invasive fungal infections such as aspergillosis, candidiasis, and cryptococcal meningitis.
• Topical Preparations: Used in creams, ointments, and lotions for cutaneous fungal infections.
• Ophthalmic Solutions: Formulated in eye drops for the treatment of fungal keratitis.
• Research & Development: A critical reference standard and tool in microbiological, pharmacological, and antifungal resistance studies.
• Veterinary Medicine: Employed in antifungal treatments for animals.
• Cell Culture & Microbiology: Selective agent in certain laboratory media and protocols.

Basic Information

Product Name	Amphotericin B
CAS No.	1397-89-3
Molecular Formula	C47H73NO17
Molecular Weight	924.09 g/mol
Synonyms	Amphotericin B; Amphotericin; Amphotericin B complex; Amphotericin A; Fungilin; Fungizone; Ampho B; Ampho-Moronal; Anfungin; Amphocin; Amphotercin B; NSC 527017; Antibiotic A 56268; 1397-89-3
EINECS	215-742-2

Quality Control

Our Amphotericin B is manufactured and tested to meet stringent pharmaceutical-grade standards, including USP/EP monographs. Every batch undergoes comprehensive analytical testing for identity, potency, purity, and specific impurities. A detailed Certificate of Analysis (COA) is provided, confirming compliance with all release specifications. Our quality system adheres to cGMP principles to ensure consistency and reliability for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and degradation. For long-term stability, desiccate to protect from moisture. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Specific Impurities (HPLC)	Individual unknown ≤ 0.5%; Total impurities ≤ 5.0%
Biological Potency	Contact for details
Bacterial Endotoxins	< 5.0 EU/mg (for parenteral grades)
Sterility	Sterile (for sterile-finished grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.