Description

S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (3S)-3-hydroxyhexanethioate is a sophisticated nucleotide-based prodrug compound designed for targeted therapeutic delivery. This molecule is engineered to enhance the bioavailability and cellular uptake of its active metabolite, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by biopharmaceutical companies and research institutions focused on antiviral and anticancer therapies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation antiviral prodrugs.
• Antiviral Research: Investigated for its potential role in the development of nucleotide analogs targeting viral polymerases.
• Oncology Drug Discovery: Used in research programs aimed at creating targeted chemotherapeutic agents that minimize systemic toxicity.
• Prodrug Development: A model compound for studying strategies to improve membrane permeability and intracellular activation of nucleoside monophosphates.
• Biochemical Research: Employed in enzymatic studies and as a tool compound to investigate nucleotide metabolism pathways.
• Preclinical Development: Supports pharmacokinetic and pharmacodynamic studies for novel therapeutic candidates.

Basic Information

Product Name	S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (3S)-3-hydroxyhexanethioate
CAS No.	74875-70-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Adenosine monophosphate prodrug derivative; Nucleotide phosphoramidate; Hexanethioate prodrug of AMP; GS-7340 intermediate (related analog); (2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl dihydrogen phosphate prodrug; S-ATE prodrug; Aryloxy phosphoramidate of adenosine; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (3S)-3-hydroxyhexanethioate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, store at 2-8°C. The container should be kept in a dry, well-ventilated area. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.