Description

[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[(3S)-3-hydroxydodecanoyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid is a sophisticated nucleotide-based compound, representing a key intermediate in advanced biochemical synthesis and pharmaceutical research. Its complex structure, featuring a purine base linked to a modified sugar-phosphate backbone with a lipophilic chain, makes it invaluable for the development of novel therapeutic agents and biochemical probes. This high-purity compound is primarily sought by research institutions and pharmaceutical developers working on nucleotide analogs, prodrug strategies, and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleotide-based prodrugs and antiviral agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, polymerases, and other nucleotide-processing enzymes.
• Prodrug Development: Serves as a model compound for designing lipophilic nucleotide prodrugs to enhance cellular uptake and bioavailability.
• Antiviral Agent Synthesis: A precursor in the research and development pipeline for potential therapeutics targeting viral replication mechanisms.
• Labeled Compound Synthesis: Can be used to create isotopically labeled (e.g., 13C, 15N, 32P) versions for metabolic tracing and pharmacokinetic studies.
• Conjugate Chemistry: The reactive functional groups allow for conjugation to carriers, antibodies, or nanoparticles for targeted delivery applications.

Basic Information

Item	Details
Product Name	[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[(3S)-3-hydroxydodecanoyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
CAS No.	72059-49-5
Molecular Formula	C31H53N7O17P3S
Molecular Weight	920.78 g/mol
Synonyms	Adenosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-5'-O-[hydroxy[[hydroxy(3-hydroxy-2,2-dimethyl-3-[[2-[[2-[(3S)-3-hydroxydodecanoyl]thio]ethyl]amino]-2-oxoethyl]amino)phosphinyl]oxy]phosphinyl], 5'→5'-ester with 3'-azido-3'-deoxythymidine (5'); 3'-Azido-3'-deoxythymidine 5'-(P1-adenosine-5'-) P3-(3-hydroxy-2,2-dimethyl-3-[[2-[[2-[(3S)-3-hydroxydodecanoyl]thio]ethyl]amino]-2-oxoethyl]amino) triphosphate; AZT-AH-dC TP; Nucleotide Prodrug Intermediate; Lipophilic Nucleotide Triphosphate Analog.
EINECS	Contact for details

Quality Control

Our [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[(3S)-3-hydroxydodecanoyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid is manufactured under strict quality management systems suitable for research and development. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and high purity. Certificates of Analysis (COA) detailing purity, impurities, and analytical data are provided with every shipment to support your critical research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.