Description

S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] oct-2-enethioate is a sophisticated, high-purity biochemical intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of nucleotide analogs and prodrugs, enabling targeted therapeutic strategies. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of antiviral agents, oncology treatments, and other innovative small-molecule therapies.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleotide-based prodrugs and active pharmaceutical ingredients (APIs).
• Antiviral Drug Research: Used in the development of next-generation antiviral compounds targeting a range of viral pathogens.
• Oncology Therapeutics: Serves as a building block for creating targeted cancer therapies that interfere with cellular nucleotide metabolism.
• Biochemical Research: Employed in academic and industrial laboratories to study enzyme mechanisms, particularly those involving nucleotide kinases and transferases.
• Prodrug Development: Integral to designing masked phosphate derivatives that enhance drug bioavailability and tissue-specific delivery.
• Labeled Compound Synthesis: A starting material for synthesizing isotopically labeled (e.g., deuterated, C13) compounds for metabolic and pharmacokinetic studies.

Basic Information

Product Name	S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] oct-2-enethioate
CAS No.	66060-79-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Nucleotide Prodrug Intermediate; Adenosine Monophosphate Prodrug Derivative; SATE Prodrug of AMP; (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-adenosine cyclic phosphate prodrug; GS-7340 Intermediate; Tenofovir Alafenamide (TAF) Related Compound; Phosphoramidate Prodrug Building Block; Acyclic Nucleoside Phosphonate Precursor
EINECS	Contact for details

Quality Control

Our S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] oct-2-enethioate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.