Description

[1aR,3S,4Z,5aR,8aR,9R,10aR,(-)]-3-Acetoxy-1aβ,2,3,5aα,7,8,8aβ,9,10,10a-decahydro-4,10aα-dimethyl-8-methylene-7-oxooxireno[5,6]cyclodeca[1,2-b]furan-9-ol 2-methylpropionate is a complex, high-purity sesquiterpene lactone derivative with significant biological activity. This compound is valued for its role as a key synthetic intermediate and reference standard in advanced pharmaceutical research and development. It is essential for researchers and manufacturers in the life sciences sector requiring precise, high-quality building blocks for drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel therapeutic agents, particularly in oncology and anti-inflammatory drug development.
• Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in academic and industrial research to study structure-activity relationships (SAR) and biological pathways involving sesquiterpene lactones.
• Natural Product Synthesis: Acts as a key chiral building block for the total synthesis of complex natural products and their analogs.
• Active Pharmaceutical Ingredient (API) Development: Investigated for potential direct use in the development of new APIs due to its bioactive core structure.

Basic Information

Item	Detail
Product Name	[1aR,3S,4Z,5aR,8aR,9R,10aR,(-)]-3-Acetoxy-1aβ,2,3,5aα,7,8,8aβ,9,10,10a-decahydro-4,10aα-dimethyl-8-methylene-7-oxooxireno[5,6]cyclodeca[1,2-b]furan-9-ol 2-methylpropionate
CAS No.	54153-71-8
Molecular Formula	C22H28O7
Molecular Weight	404.46 g/mol
Synonyms	(-)-3-Acetoxy-1aβ,2,3,5aα,7,8,8aβ,9,10,10a-decahydro-4,10aα-dimethyl-8-methylene-7-oxooxireno[5,6]cyclodeca[1,2-b]furan-9-ol 2-methylpropionate; Parthenolide 3-acetate 9-isobutyrate; Parthenolide derivative; 3-Acetylparthenolide 9-isobutyrate; Sesquiterpene lactone ester; Oxireno[5,6]cyclodeca[1,2-b]furan derivative; Isobutyric acid, ester with parthenolide analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our [1aR,3S,4Z,5aR,8aR,9R,10aR,(-)]-3-Acetoxy-1aβ,2,3,5aα,7,8,8aβ,9,10,10a-decahydro-4,10aα-dimethyl-8-methylene-7-oxooxireno[5,6]cyclodeca[1,2-b]furan-9-ol 2-methylpropionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and structural confirmation via NMR and MS, to ensure it meets the stringent requirements for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.