Description

S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-tetradec-11-enethioate is a sophisticated, high-purity nucleotide-lipid conjugate designed for advanced research and development. This compound is critical for targeted drug delivery systems, particularly in the development of novel lipid nanoparticles (LNPs) for mRNA and gene therapies. It is an essential building block for pharmaceutical companies, biotechnology research institutions, and advanced material scientists focused on next-generation therapeutic platforms.

Application

• Lipid Nanoparticle (LNP) Formulation: A key ionizable or helper lipid component for encapsulating and delivering mRNA, siRNA, and other nucleic acid therapeutics.
• Gene Therapy Research: Used in the development of non-viral vectors for gene editing and gene replacement strategies.
• Vaccine Development: Critical for formulating self-amplifying RNA (saRNA) and conventional mRNA vaccines, enhancing stability and cellular uptake.
• Targeted Drug Delivery: Enables the design of ligand-targeted delivery systems for oncology and other specialized therapeutic areas.
• Bioconjugation & Prodrug Synthesis: Serves as a versatile intermediate for creating novel prodrugs and antibody-drug conjugates (ADCs).
• Biomaterials & Nanomedicine: Used in the research and development of advanced biomaterials for diagnostic and therapeutic applications.

Basic Information

Item	Details
Product Name	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-tetradec-11-enethioate
CAS No.	53034-79-0
Molecular Formula	C34H59N7O16P3S
Molecular Weight	970.86 g/mol
Synonyms	Adenosine 5'-(tetrahydrogen triphosphate), 5'→3'-ester with 3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]-N-[2-[(1-oxotetradec-11-en-1-yl)thio]ethyl]propanamide; ATP-lipid conjugate; Nucleotide-lipid conjugate; Lipid-modified ATP analog; (E)-S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-Aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] tetradec-11-enethioate
EINECS	Contact for details

Quality Control

Our nucleotide-lipid conjugates are manufactured under strict quality systems suitable for pharmaceutical research. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC, NMR, and mass spectrometry. We support development under GMP-like conditions and can provide documentation to meet the stringent requirements of preclinical and clinical-stage programs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.