Description

S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-oxodecanethioate is a sophisticated nucleotide-lipid conjugate, representing a key intermediate in the development of advanced therapeutic and diagnostic agents. This compound is critical for researchers and manufacturers working on targeted drug delivery systems, particularly in the fields of oligonucleotide and mRNA therapeutics. Its unique structure, combining a nucleotide moiety with a lipophilic thioester tail, makes it essential for synthesizing prodrugs and creating novel lipid nanoparticles (LNPs). This high-purity biochemical is primarily utilized by pharmaceutical R&D teams and fine chemical suppliers serving the biotechnology sector.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of nucleotide prodrugs and advanced therapeutic oligonucleotides.
• Lipid Nanoparticle (LNP) Formulation: Used in the research and development of novel ionizable or functionalized lipids for mRNA and siRNA delivery systems.
• Targeted Drug Delivery: Serves as a conjugate for creating targeted therapies, enabling specific cellular uptake and release mechanisms.
• Bioconjugation Chemistry: Employed in the development of diagnostic probes and bioconjugates due to its reactive thioester group.
• Biochemical Research: A valuable tool for academic and industrial research into cell signaling, nucleotide metabolism, and membrane biology.
• Antiviral & Anticancer Agent Development: Investigated as a precursor for novel nucleoside analog-based treatments.

Basic Information

Product Name	S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-oxodecanethioate
CAS No.	50411-91-1
Molecular Formula	C₃₀H₅₂N₇O₁₇P₃S
Molecular Weight	931.76 g/mol
Synonyms	Adenosine 5'-(tetrahydrogen triphosphate), 5'→3'-ester with 3-[[4-[[3-[(3-oxodecanoyl)thio]ethyl]amino]-3-oxopropyl]amino]-2-hydroxy-3,3-dimethylbutanoic acid; 3'-O-{3-[[4-[[3-[(3-oxodecanoyl)thio]ethyl]amino]-3-oxopropyl]amino]-2-hydroxy-3,3-dimethylbutanoyl}adenosine 5'-triphosphate; ATP-lipid conjugate; Nucleotide-lipid conjugate; Adenosine triphosphate 3'-lipid ester; 3'-O-(3,3-dimethyl-2-hydroxy-4-[[3-[(3-oxodecanoyl)thio]ethyl]carbamoyl]butanoyl) ATP
EINECS	Contact for details

Quality Control

Our S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-oxodecanethioate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We ensure compliance with relevant guidelines for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.