Description

[(2R,3R,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phosphoryl]oxy-phosphinic acid is a high-purity nucleotide derivative essential for advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and reference standard in the synthesis and study of nucleic acid analogs and enzyme substrates. It is primarily utilized by research institutions and pharmaceutical companies engaged in metabolic pathway studies, antiviral drug discovery, and enzymology. Our supply ensures consistent quality and reliable availability for your most demanding projects.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays, particularly for kinases and other phosphoryl-transfer enzymes.
• Pharmaceutical Intermediates: Serves as a key precursor in the synthesis of novel nucleoside-based therapeutics, including potential antiviral and anticancer agents.
• Metabolomics & Diagnostic Development: Acts as a critical reference standard for the identification and quantification of nucleotide metabolites in complex biological samples.
• Enzyme Mechanism Studies: Employed to investigate the catalytic mechanisms of glycosyltransferases and other sugar-nucleotide utilizing enzymes.
• Cell Signaling Research: Utilized in studies focused on purinergic signaling pathways and intracellular energy metabolism.
• Academic & Industrial R&D: Fundamental reagent for exploring nucleotide chemistry and developing new biocatalytic processes.

Basic Information

Product Name	[(2R,3R,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phosphoryl]oxy-phosphinic acid
CAS No.	5750-57-2
Molecular Formula	C16H25N5O16P2
Molecular Weight	605.34 g/mol
Synonyms	GDP-Adenosine; Guanosine 5'-[β-L-fucopyranosyl diphosphate]; Guanosine diphosphate fucose; GDP-Fucose; Guanosine 5'-(trihydrogen diphosphate), mono(6-deoxy-β-L-galactopyranosyl) ester; 6-Deoxy-β-L-galactopyranosyl guanosine 5'-pyrophosphate; β-L-Fucopyranosyl guanosine 5'-pyrophosphate
EINECS	Contact for details

Quality Control

Every batch of our nucleotide derivatives is produced and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our quality protocols are designed to meet the exacting standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 90.0% (anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.