Description

S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-hexadec-2-enethioate is a sophisticated nucleotide-lipid conjugate, representing a critical building block in advanced biochemical research and therapeutic development. This compound matters for its role as a key intermediate in the synthesis of novel prodrugs and targeted delivery systems, particularly for nucleoside analogs. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antiviral therapies, oncology, and the development of next-generation lipid nanoparticle (LNP) formulations for nucleic acid delivery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleotide prodrugs for antiviral and anticancer applications.
• Lipid Nanoparticle (LNP) Research: Used in the development and optimization of novel ionizable or permanently charged lipids for mRNA, siRNA, and other nucleic acid delivery platforms.
• Bioconjugation & Prodrug Development: Enables the targeted conjugation of nucleoside analogs to lipophilic carriers to enhance cellular uptake, bioavailability, and tissue specificity.
• Biochemical Tool Compound: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and lipid signaling pathways.
• Advanced Drug Delivery Systems (DDS): Incorporated into micellar, liposomal, or other nanocarrier systems to improve the pharmacokinetic profile of therapeutic agents.
• Medicinal Chemistry Research: Provides a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting viral polymerases or cellular kinases.

Basic Information

Item	Details
Product Name	S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-hexadec-2-enethioate
CAS No.	4460-95-1
Molecular Formula	C35H61N7O16P3S
Molecular Weight	984.90 g/mol
Synonyms	Adenosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-, 5'→5'-ester with 3-[[4-[[2-[[(1E)-1-oxo-2-hexadecen-1-yl]thio]ethyl]amino]-3-hydroxy-3-methyl-1-oxobutyl]amino]propanoic acid; Lipid-modified dATP analog; Nucleotide-lipid conjugate; 2'-Deoxyadenosine-5'-triphosphate lipid prodrug intermediate; dATP-C16 lipid conjugate; (E)-S-(2-(3-(4-((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanamido)propanamido)ethyl) hexadec-2-enethioate
EINECS	Contact for details

Quality Control

Our S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-hexadec-2-enethioate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.