Description

[[(2S,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-[[[(2S,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-phosphinic acid is a high-purity nucleotide derivative, specifically a cyclic dinucleotide, essential for advanced biochemical research and pharmaceutical development. Its primary value lies in its role as a key intermediate or reference standard for studying intracellular signaling pathways and developing novel therapeutics. This compound is critical for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require reliable, high-quality building blocks for nucleotide-based drug discovery and diagnostic applications.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel nucleotide-based therapeutics, including potential antiviral and anticancer agents.
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies, particularly those involving nucleotide metabolism and cyclic dinucleotide signaling pathways (e.g., cGAS-STING).
• Diagnostic Development: Employed in the development and calibration of diagnostic assays and kits that detect or quantify specific nucleotide sequences or enzymatic activities.
• Cell Signaling Studies: Acts as a tool compound to investigate the role of cyclic dinucleotides in innate immune responses and other cellular communication processes.
• Academic & Institutional Research: Provides a high-purity material for universities and research institutes conducting fundamental research in molecular biology and medicinal chemistry.
• GMP Manufacturing: Suitable for use under Good Manufacturing Practice (GMP) guidelines for the production of active pharmaceutical ingredients (APIs) in clinical-stage products.

Basic Information

Product Name	[[(2S,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-[[[(2S,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-phosphinic acid
CAS No.	4130-19-2
Molecular Formula	C20H25N10O16P3
Molecular Weight	754.39 g/mol
Synonyms	Cyclic di-AMP; c-di-AMP; Cyclic diadenylic acid; Cyclic diadenosine monophosphate; Cyclic diguanylate; Cyclic diguanylic acid; 3',5'-Cyclic diguanylic acid; Cyclic diguanylate (c-di-GMP) analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our [[(2S,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-[[[(2S,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-phosphinic acid is produced and tested under a rigorous quality management system to ensure batch-to-batch consistency and purity suitable for research and GMP applications. All products undergo comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with your specified requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 10 EU/mg
Bioburden	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.