Description

1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDINYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE is a high-purity, complex naphthyridine derivative hydrochloride salt, serving as a critical pharmaceutical intermediate or reference standard in advanced research and development. Its intricate molecular structure makes it a valuable building block for synthesizing novel bioactive compounds, particularly in oncology and targeted therapy programs. This product is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on drug discovery.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of novel kinase inhibitors and other targeted therapeutic agents.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in pharmaceutical manufacturing.
• Biochemical Research: Tool compound for studying enzyme inhibition, cellular signaling pathways, and structure-activity relationships (SAR).
• Preclinical Development: Serves as a starting material or intermediate in the synthesis of candidate drugs for pharmacological and toxicological evaluation.
• Academic Research: Employed in university and institutional labs for medicinal chemistry projects and the discovery of new chemical entities.
• Custom Synthesis: Basis for the tailored synthesis of analogs and derivatives for specialized client research programs.

Basic Information

Item	Detail
Product Name	1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDINYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
CAS No.	324572-92-1
Molecular Formula	C32H31N5O7 • HCl
Molecular Weight	634.08 g/mol (free base: 597.62 g/mol)
Synonyms	Methyl 1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-[(2-pyrimidinyl)methoxy]-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate hydrochloride; 2,7-Naphthyridine-3-carboxylic acid derivative hydrochloride; CAS 324572-92-1; Kinase inhibitor intermediate hydrochloride salt; Naphthyridine-pyridine-pyrimidine tricyclic compound HCl salt
EINECS	Contact for details

Quality Control

Our 1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDYNYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere if specified and stored in a low-humidity environment. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0% (Area Percent)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.