Description

5-(6-aminopurin-9-yl)-2-[[[[3-[2-(2-dec-2-enoylsulfanylethylcarbamoyl)ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propoxy]-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-4-hydroxy-oxolan-3-yl]oxyphosphonic acid is a sophisticated, high-purity nucleotide derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound matters for its role as a key intermediate or modified building block in the synthesis of novel therapeutic agents, particularly in areas like antiviral and anticancer research. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical sectors working on nucleotide-based drug discovery and development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleotide analog drugs targeting viral infections and cancers.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and nucleotide processing.
• Proteomics & Molecular Biology: Can be utilized in the development of labeled probes or affinity tags for studying protein-nucleic acid interactions.
• Antiviral Drug Development: Acts as a precursor for modified nucleosides designed to inhibit viral polymerases (e.g., for hepatitis or herpes viruses).
• Oncology Research: Investigated for incorporation into oligonucleotides or as a standalone agent to disrupt cancer cell DNA/RNA synthesis.
• Diagnostic Reagent Synthesis: Potential use in creating specialized nucleotides for diagnostic kits and assays.

Basic Information

Product Name	5-(6-aminopurin-9-yl)-2-[[[[3-[2-(2-dec-2-enoylsulfanylethylcarbamoyl)ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propoxy]-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-4-hydroxy-oxolan-3-yl]oxyphosphonic acid
CAS No.	37325-74-9
Molecular Formula	C31H51N8O16P3S
Molecular Weight	940.79 g/mol
Synonyms	Adenosine 5'-(trihydrogen diphosphate), 2'-deoxy-5'-O-[hydroxy[[hydroxy[3-hydroxy-3-[[2-[[2-[(1-oxo-2-decen-1-yl)thio]ethyl]amino]-2-oxoethyl]amino]-2,2-dimethylpropoxy]phosphinyl]oxy]phosphinyl]-, P'→5'-ester with 3-amino-3-deoxy-D-ribofuranose; Modified S-Acyl-2-thioethyl (SATE) Pronucleotide of 2'-Deoxyadenosine; 2'-Deoxyadenosine SATE pronucleotide derivative; dA-SATE Intermediate; Nucleotide Prodrug Intermediate; 37325-74-9; CAS 37325-74-9
EINECS	Contact for details

Quality Control

Our production of this high-value nucleotide derivative adheres to strict quality management systems, ensuring batch-to-batch consistency for research and development. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic and potentially light-sensitive nature, the product should be allowed to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 90.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.