Description

S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (3S)-3-hydroxyhexadecanethioate is a sophisticated nucleotide-lipid conjugate, representing a key intermediate in advanced pharmaceutical and biochemical research. Its primary value lies in its role as a critical building block for the synthesis of novel prodrugs and targeted therapeutic agents, particularly in the development of nucleotide-based antivirals and anticancer compounds. This high-purity specialty chemical is essential for research institutions, pharmaceutical R&D laboratories, and manufacturers focused on innovative drug delivery systems and metabolic pathway studies.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of nucleotide prodrugs and targeted antiviral/anticancer therapeutics.
• Biochemical Research: Used as a tool compound for studying nucleotide transport, cellular uptake mechanisms, and intracellular metabolism.
• Lipid-Nucleotide Conjugate Synthesis: Serves as a key starting material for creating novel conjugates designed to improve drug bioavailability and targeting.
• Prodrug Development: Employed in R&D for designing masked nucleotide analogs that are activated within specific cells or tissues.
• Antiviral Agent Research: Investigated for its potential role in the development of next-generation treatments for viral infections.
• Metabolic Pathway Analysis: Utilized as a tracer or standard in analytical studies of nucleotide and phospholipid metabolism.

Basic Information

Product Name	S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (3S)-3-hydroxyhexadecanethioate
CAS No.	35106-50-4
Molecular Formula	C₃₇H₆₈N₇O₁₇P₃S
Molecular Weight	1000.0 g/mol (approx.)
Synonyms	1-O-Hexadecyl-2-O-methyl-rac-glycero-3-phosphatidic acid; Nucleotide-lipid conjugate 35106-50-4; Adenine nucleotide lipid derivative; (3S)-3-Hydroxyhexadecanethioic acid S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] ester; Acylated nucleotide prodrug intermediate; Lipid-modified adenosine monophosphate analog
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent quality protocols suitable for pharmaceutical research applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing specifications for purity, identity, and related substances. We support development under cGMP guidelines where required, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. Due to its hygroscopic and moisture-sensitive nature, containers must be sealed under an inert atmosphere (argon or nitrogen) after each use to prevent degradation. For long-term stability, desiccants are recommended within the storage unit.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.