Description

2H-Cyclopenta[b]furan-2-one, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(1Z,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]hexahydro-, (3aR,4R,5R,6aS)- is a highly specialized, stereochemically defined synthetic intermediate featuring dual tert-butyldimethylsilyl (TBDMS) protecting groups and a trifluoromethylphenoxy moiety. This compound is critical for enabling complex, multi-step organic syntheses where precise control over stereochemistry and functional group protection is paramount. It is primarily utilized by pharmaceutical and advanced agrochemical research organizations for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex, biologically active molecules, particularly for drug discovery programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoromethyl group enhances bioavailability and metabolic stability.
• Advanced Material Synthesis: Serves as a precursor for specialty polymers and liquid crystals, leveraging its rigid, functionalized core structure.
• Process Chemistry & Scale-up: Employed in route scouting and optimization studies for the commercial production of fine chemicals.
• Academic & Contract Research: A valuable reagent for methodological studies in synthetic organic chemistry, especially in stereoselective transformations and protecting group strategies.

Basic Information

Product Name	2H-Cyclopenta[b]furan-2-one, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[(1Z,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]hexahydro-, (3aR,4R,5R,6aS)-
CAS No.	2557327-14-5
Molecular Formula	C30H45F3O5Si2
Molecular Weight	598.85 g/mol
Synonyms	(3aR,4R,5R,6aS)-5-((tert-Butyldimethylsilyl)oxy)-4-((Z)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one; TBDMS-protected trifluoromethylphenoxy butenyl lactone; CAS 2557327-14-5; Protected lactone intermediate; Fluorinated silyl ether intermediate; Bicyclic lactone with TBDMS groups.
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and analyzed under strict quality management systems to ensure identity, purity, and stereochemical integrity. Our quality control protocols include advanced chromatographic and spectroscopic methods to guarantee batch-to-batch consistency for your critical research and development projects. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC/NMR), stereochemical confirmation, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the certificate of analysis. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.