Description

1,2-Cyclopentanediol, 3-[7-[[(1S,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)- is a sophisticated, high-purity chiral intermediate designed for advanced pharmaceutical synthesis. This compound is critical for research and development in medicinal chemistry, particularly for constructing complex molecules with specific stereochemistry. It is primarily sought by pharmaceutical companies and contract research organizations (CROs) engaged in the development of novel therapeutic agents, especially within kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Process Chemistry Development: Serves as a critical chiral starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Potential use as a tool compound or probe in enzymatic and cellular assays to study biological pathways.
• Custom Synthesis: Basis for the preparation of more complex, proprietary analogs and derivatives for specialized research programs.

Basic Information

Product Name	1,2-Cyclopentanediol, 3-[7-[[(1S,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)-
CAS No.	2435586-40-4
Molecular Formula	C24H28F2N6O3S
Molecular Weight	518.58 g/mol
Synonyms	(1S,2S,3R,5S)-5-(2-Hydroxyethoxy)-3-[7-[[(1S,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]cyclopentane-1,2-diol; 1,2-Cyclopentanediol derivative (kinase inhibitor intermediate); Triazolopyrimidine-cyclopropylamine conjugate; Advanced chiral pharmaceutical building block
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality systems to ensure batch-to-batch consistency and traceability. Certificates of Analysis (COA) are provided with each batch, detailing purity, chiral purity, and impurity profiles as determined by advanced analytical techniques including HPLC, LC-MS, and NMR. Our quality commitment aligns with the standards required for cGMP starting material evaluation in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. For long-term storage, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.