Description

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide is a sophisticated bifunctional small molecule designed for targeted protein degradation research. This compound integrates a ligand for a protein of interest with a cereblon (CRBN) E3 ligase recruiting moiety, making it a critical tool for the development of Proteolysis-Targeting Chimeras (PROTACs). It is essential for pharmaceutical R&D teams focused on oncology, neurodegenerative diseases, and other therapeutic areas where targeted protein degradation offers a novel therapeutic strategy.

Application

• PROTAC Development: Serves as a key chemical probe for designing and optimizing bifunctional degraders targeting specific disease-relevant proteins.
• Chemical Biology Research: Used to study ubiquitin-proteasome system (UPS) engagement, ternary complex formation, and degradation kinetics.
• Oncology Drug Discovery: A foundational building block for creating novel therapeutics aimed at degrading oncoproteins considered "undruggable" by conventional inhibitors.
• Preclinical Studies: Enables in vitro and in vivo proof-of-concept studies for targeted protein degradation pathways.
• E3 Ligase Profiling: Useful for investigating the specificity and efficiency of CRBN-mediated protein degradation.
• Hit-to-Lead Optimization: Provides a versatile scaffold for medicinal chemists to modify linker length and composition to improve degradation potency and pharmacokinetic properties.

Basic Information

Product Name	N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
CAS No.	2250025-88-6
Molecular Formula	C44H52ClN11O9S
Molecular Weight	946.47 g/mol
Synonyms	PROTAC Molecule 2250025-88-6; Bifunctional Degrader; CRBN-based PROTAC Building Block; Cereblon Ligase Recruiter; Targeted Protein Degradation Compound; Heterobifunctional Molecule; (5-Chloro-N2-(4-(4-(2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)ethoxy)ethoxy)ethyl)piperazin-1-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine); PROTAC Linker Conjugate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade chemicals. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing purity, HPLC chromatograms, and NMR data are available upon request. We adhere to strict quality management protocols suitable for pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere such as argon or nitrogen. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with molecular structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.