Description

4-(4-(4-(4-(((3S,5S)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2R,3R)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one is a sophisticated, high-purity advanced pharmaceutical intermediate (API intermediate) featuring a complex molecular architecture with multiple chiral centers and heterocyclic motifs. This compound is of critical importance for the research and development of novel therapeutic agents, particularly in the fields of antifungal and other small-molecule drug discovery. It is specifically designed for use by pharmaceutical R&D teams, process chemists, and manufacturers requiring a reliable, high-quality building block for complex synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for antifungal drug candidates.
• Antifungal Research: Used in the discovery and development of new triazole-based antifungal agents targeting fungal CYP51 enzymes.
• Medicinal Chemistry: A valuable substrate for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Development: Employed in scaling up synthetic routes and optimizing manufacturing processes for complex drug molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials or commercial APIs.
• Biochemical Research: May be used as a reference standard or probe in biochemical assays to study enzyme inhibition and mechanism of action.

Basic Information

Item	Details
Product Name	4-(4-(4-(4-(((3S,5S)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2R,3R)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
CAS No.	2243785-97-7
Molecular Formula	C38H42F2N8O4
Molecular Weight	700.79 g/mol
Synonyms	CAS 2243785-97-7; (3S,5S,2R,3R)-Triazolyl-tetrahydrofuran-piperazine-triazolone derivative; Advanced Antifungal Intermediate; Difluorophenyl triazole piperazine intermediate; Complex Chiral Triazole Building Block; (S,S)-(R,R)-Triazolone API Intermediate
EINECS	Contact for details

Quality Control

Our 4-(4-(4-(4-(((3S,5S)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2R,3R)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and comprehensive impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and moisture uptake. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.