Description

Ketoconazole is a synthetic imidazole antifungal agent widely recognized for its broad-spectrum activity against a variety of pathogenic fungi and yeasts. Its primary commercial value lies in its effectiveness as a key active pharmaceutical ingredient (API) for both systemic and topical antifungal formulations. This compound is essential for manufacturers in the pharmaceutical, veterinary medicine, and personal care industries, where it is used to develop treatments for conditions like athlete's foot, ringworm, seborrheic dermatitis, and systemic fungal infections. Ketoconazole CAS NO 65277-42-1 is supplied with a focus on high purity and consistent quality to meet stringent global regulatory standards.

Application

• Active Pharmaceutical Ingredient (API) in prescription and over-the-counter antifungal creams, ointments, and shampoos.
• Key component in veterinary pharmaceuticals for treating fungal infections in livestock and companion animals.
• Raw material for the synthesis of more advanced antifungal agents and derivatives in research chemistry.
• Incorporated into medicated soaps and topical solutions for dermal antifungal care.
• Used in agricultural fungicides for protecting certain high-value crops, subject to regional regulations.
• Reference standard in analytical laboratories for quality control and method development.

Basic Information

Product Name	Ketoconazole
CAS No.	65277-42-1
Molecular Formula	C26H28Cl2N4O4
Molecular Weight	531.43 g/mol
Synonyms	cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; (±)-cis-1-Acetyl-4-[p-[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; R 41400; Nizoral; Fungarest; Ketoderm; Ketozole; Travocort
EINECS	265-667-4

Quality Control

Our Ketoconazole is manufactured under a strict quality management system and can be supplied to meet various pharmacopoeial standards, including USP and EP. Each batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, to ensure it meets the required specifications for pharmaceutical use. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.