Description

(1R,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione methanesulfonate is a high-purity, complex heterocyclic compound with a defined stereochemistry, serving as a critical advanced pharmaceutical intermediate or reference standard in modern drug discovery. Its intricate fused-ring structure, incorporating fluorine and a methanesulfonate salt, makes it a valuable building block for the development of novel therapeutic agents, particularly in oncology and targeted therapies. This compound is essential for research institutions, pharmaceutical R&D laboratories, and contract manufacturing organizations (CMOs) engaged in the synthesis of potent, next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of novel anticancer and antiviral agents.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural moiety for new chemical entities (NCEs) under preclinical and clinical investigation.
• Biochemical Research: Used as a high-affinity ligand or probe in enzymatic and receptor binding studies due to its complex, drug-like structure.
• Reference Standard: Provides an essential benchmark for quality control, method development, and regulatory compliance in analytical laboratories.
• Process Chemistry & Scale-Up: Supports route scouting and optimization studies for the efficient, large-scale synthesis of target molecules.
• Academic Research: Facilitates studies in medicinal chemistry, exploring structure-activity relationships (SAR) and novel heterocyclic scaffolds.

Basic Information

Product Name	(1R,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione methanesulfonate
CAS No.	2231666-58-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(1R,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione methanesulfonate salt; Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline methanesulfonate derivative; Fluorinated indolizinoquinoline methanesulfonate; Topoisomerase inhibitor intermediate (structural analog); Complex heterocyclic methanesulfonate salt; CAS 2231666-58-1.
EINECS	Contact for details

Quality Control

Our (1R,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione methanesulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and related substances. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.