Description

2H-Imidazol-2-one, 1-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-4,5,6,7-tetrahydro-4-methyl-2H-pyrazolo[4,3-c]pyridin-3-yl]-3-(4-fluoro-1-methyl-1H-indazol-5-yl)-1,3-dihydro-, hydrochloride (1:1) is a high-purity, non-racemic pharmaceutical intermediate and active pharmaceutical ingredient (API) with a complex heterocyclic structure. This compound is of significant commercial interest for its role in the research and development of novel therapeutic agents, particularly in oncology and other targeted disease areas. It is primarily utilized by pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and advanced fine chemical suppliers engaged in the synthesis of complex drug candidates.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Active Pharmaceutical Ingredient (API) Development: Serves as the core active moiety for preclinical and clinical-stage pharmaceutical development programs.
• Oncology Research: Key precursor in the development of targeted cancer therapies, leveraging its specific molecular architecture.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Used as a warhead or linker component in the design of novel bifunctional molecules for targeted protein degradation.
• Process Chemistry & Scale-Up: Supplied to CDMOs for process optimization, route scouting, and cGMP manufacturing campaigns.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in regulatory submissions.

Basic Information

Item	Details
Product Name	2H-Imidazol-2-one, 1-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-4,5,6,7-tetrahydro-4-methyl-2H-pyrazolo[4,3-c]pyridin-3-yl]-3-(4-fluoro-1-methyl-1H-indazol-5-yl)-1,3-dihydro-, hydrochloride (1:1)
CAS No.	2212022-57-4
Molecular Formula	C27H26F2N8O · HCl
Molecular Weight	545.01 g/mol (Free base: 508.55 g/mol)
Synonyms	(S)-1-(2-(4-Fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-3-(4-fluoro-1-methyl-1H-indazol-5-yl)imidazolidin-2-one hydrochloride; PF-06873600 (Free base form); PF06873600; PF 06873600; CDK2/4/6 Inhibitor Intermediate; (4S)-1,3-Bis(heteroaryl)imidazolidin-2-one hydrochloride derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency suitable for pharmaceutical development. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and LC-MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, chiral purity, and impurity profiles. We support development activities with regulatory-grade documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.