Description

((1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5,6-dimethyl-6-(trimethylsilyloxy)hept-3-en-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diyl)bis(oxy)bis(tert-butyldimethylsilane) is a highly specialized, advanced pharmaceutical intermediate featuring a complex, stereochemically defined molecular architecture. This compound is of critical importance for its role as a key building block in the synthesis of novel vitamin D analogs and other high-value therapeutic agents. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing next-generation treatments for conditions like osteoporosis, psoriasis, and cancer.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of calcitriol analogs and other secosteroids.
• Drug Discovery & Development: Used in medicinal chemistry research to create and test new chemical entities with vitamin D receptor (VDR) activity.
• Process Chemistry: Serves as a high-purity starting material or intermediate in the scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing routes.
• Biochemical Research: Employed in studies investigating the molecular mechanisms of vitamin D metabolism and signaling pathways.
• Fine Chemical Synthesis: Utilized for constructing complex, polyfunctional molecules requiring precise stereochemical control.

Basic Information

Product Name	((1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5,6-dimethyl-6-(trimethylsilyloxy)hept-3-en-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diyl)bis(oxy)bis(tert-butyldimethylsilane)
CAS No.	2186604-89-5
Molecular Formula	C44H78O3Si3
Molecular Weight	739.34 g/mol
Synonyms	1,3-Bis-O-(tert-butyldimethylsilyl)-5-[(E)-2-[(1R,3aS,7aR)-1-[(2R,5S,E)-5,6-Dimethyl-6-(trimethylsilyloxy)hept-3-en-2-yl]-7a-methyloctahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol; Vitamin D Intermediate (TBS Protected); (1R,3R)-5-[(E)-2-[(1R,3aS,7aR)-1-[(2R,5S,E)-5,6-Dimethyl-6-(trimethylsiloxy)hept-3-en-2-yl]-7a-methyloctahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diyl bis(tert-butyldimethylsilyl) ether; Secosteroid Synthesis Intermediate; TBS-Protected CD-Ring Synthon.
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and structural integrity. Our quality system emphasizes rigorous analytical verification using techniques like HPLC, NMR, and MS to confirm identity, purity, and stereochemical configuration. A comprehensive Certificate of Analysis (COA) detailing all critical parameters is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.