Description

1H-Pyrrole-1,2-dicarboxylic acid, 3-amino-4-(3aS,4S,6S,6aR)-6-(bromomethyl)-5-(1,1-dimethylethoxy)carbonyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-, 2-ethyl 1-(phenylmethyl) ester is a sophisticated, high-purity chemical intermediate characterized by its complex, multi-functional molecular architecture. This compound is of critical importance for enabling advanced synthetic pathways in pharmaceutical research and development, particularly in the synthesis of nucleoside analogs and other complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to build novel molecular entities with high stereochemical control.

Application

• Key Intermediate in Nucleoside Analog Synthesis: Serves as a crucial building block for the development of antiviral and anticancer drug candidates.
• Pharmaceutical Research & Development (R&D): Used in exploratory chemistry for constructing complex heterocyclic scaffolds with defined stereochemistry.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial production of active pharmaceutical ingredients (APIs).
• Synthesis of Prodrugs: The protected ester and bromomethyl functionalities make it valuable for designing prodrug molecules with enhanced bioavailability.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic synthesis and medicinal chemistry.
• Fine Chemical Manufacturing: Acts as a specialized intermediate for custom synthesis projects requiring high chemical purity and specific stereoisomers.

Basic Information

Product Name	1H-Pyrrole-1,2-dicarboxylic acid, 3-amino-4-(3aS,4S,6S,6aR)-6-(bromomethyl)-5-(1,1-dimethylethoxy)carbonyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-, 2-ethyl 1-(phenylmethyl) ester
CAS No.	222631-38-1
Molecular Formula	C27H34BrN3O8
Molecular Weight	608.48 g/mol
Synonyms	(3aS,4S,6S,6aR)-6-(Bromomethyl)-2,2-dimethyl-N-[(benzyloxy)carbonyl]-4-[3-(ethoxycarbonyl)-4-amino-1H-pyrrole-2-carboxamido]tetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid 1,1-dimethylethyl ester; 1H-Pyrrole-2-carboxylic acid, 3-amino-4-[(3aS,4S,6S,6aR)-6-(bromomethyl)-5-[[(1,1-dimethylethoxy)carbonyl]amino]tetrahydro-2,2-dimethyl-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl]-, 2-ethyl 1-(phenylmethyl) ester; tert-Butyl ((3aS,4S,6S,6aR)-6-(bromomethyl)-2,2-dimethyl-4-(3-(ethoxycarbonyl)-4-amino-1H-pyrrole-2-carboxamido)tetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate)benzyl carbamate derivative; Advanced nucleoside intermediate 222631-38-1; Z-D-4-Amino-5-iodo-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine precursor.
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Our rigorous testing includes identity confirmation, purity assessment, and control of critical impurities. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing specifications such as assay purity (by HPLC), enantiomeric/excess, and residual solvent levels. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry, well-ventilated place. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.