Description

(2R,3R,4R,5R)-5-[[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-2-[4-(hydrazinecarbonyl)pyridin-1-yl]-4-hydroxy-oxolan-3-olate is a sophisticated nucleotide derivative, a key building block in advanced biochemical research and pharmaceutical development. Its complex structure, featuring a nicotinamide hydrazide moiety linked to an adenosine diphosphate (ADP) analog, makes it a critical precursor for synthesizing novel enzyme inhibitors and probes targeting NAD(P)+-dependent processes. This high-purity compound is essential for researchers and manufacturers in pharmaceutical R&D, enzymology, and molecular biology who require reliable, well-characterized biochemical tools.

Application

• Biochemical Research: As a substrate analog or inhibitor in studies of NAD(P)+-utilizing enzymes such as dehydrogenases, PARPs (Poly(ADP-ribose) polymerases), and sirtuins.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor for developing novel therapeutics targeting metabolic disorders, cancer, and age-related diseases.
• Enzyme Mechanism Probes: Used to investigate catalytic mechanisms and binding sites due to its modified ADP and hydrazide functional groups.
• Diagnostic Reagent Development: Potential component in the formulation of diagnostic kits for monitoring specific enzymatic activities in clinical samples.
• Cofactor Engineering: Tool for studying and engineering biosynthetic pathways that rely on NAD(P)+ cofactors.
• Antiviral/Anticancer Agent Research: Investigated for its potential to interfere with viral or cancer cell metabolism by mimicking natural nucleotides.

Basic Information

Item	Details
Product Name	(2R,3R,4R,5R)-5-[[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-2-[4-(hydrazinecarbonyl)pyridin-1-yl]-4-hydroxy-oxolan-3-olate
CAS No.	2668-07-7
Molecular Formula	C22H28N8O16P2
Molecular Weight	738.45 g/mol
Synonyms	NAD+ analog with nicotinamide hydrazide; Adenosine diphosphate ribose nicotinoyl hydrazide derivative; 1-(5-O-{[(2R,3R,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl} dihydrogendiphosphono)-4-(hydrazinecarbonyl)pyridin-1-ium-3,5-diolate; ADP-ribose nicotinoyl hydrazide; Modified NAD+ derivative; 4-Carboxypridine adenine dinucleotide hydrazide; Research biochemical 2668-07-7
EINECS	Contact for details

Quality Control

Our production of this high-value biochemical adheres to stringent quality protocols. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. We provide comprehensive Certificates of Analysis (COA) detailing purity, impurity profiles, and analytical data. While produced under controlled conditions suitable for research use, specifications can be aligned with specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Assay-specific (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.