Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(3-aminophenyl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a complex, stereochemically defined organic intermediate featuring a fused dioxolopyrrole core, an aminophenyl group, and a protected silyloxymethyl moiety. This compound is of significant value in advanced pharmaceutical research and development, particularly as a key chiral building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, structurally sophisticated intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) or anti-infective therapies.
• Process Chemistry: Used in route scouting and optimization for the scalable synthesis of target molecules in Good Manufacturing Practice (GMP) environments.
• Agrochemical Research: Acts as a precursor in the synthesis of novel, biologically active compounds for crop protection.
• Academic & Institutional Research: Employed in medicinal chemistry programs and methodological studies exploring new synthetic transformations of complex heterocycles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring this precise molecular architecture.
• Reference Standard: Provided as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Item	Details
Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(3-aminophenyl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	188744-91-4
Molecular Formula	C24H38N2O5Si
Molecular Weight	462.66 g/mol
Synonyms	(3aS,4S,6R,6aR)-4-(3-Aminophenyl)-6-[[(tert-butyldimethylsilyl)oxy]methyl]tetrahydro-2,2-dimethyl-5H-1,3-dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester; tert-Butyl (3aS,4S,6R,6aR)-4-(3-aminophenyl)-6-[[(tert-butyldimethylsilyl)oxy]methyl]tetrahydro-2,2-dimethyl-5H-1,3-dioxolo[4,5-c]pyrrole-5-carboxylate; 5H-1,3-Dioxolo[4,5-c]pyrrole-5-carboxylic acid, 4-(3-aminophenyl)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-; TBDMS-protected aminophenyl dioxolopyrrole carboxylate; CAS 188744-91-4.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.