Description

[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-(3-hydroxypropanoylsulfanyl)ethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid is a sophisticated nucleotide analog with a complex, multi-functional structure designed for targeted biochemical interactions. This compound is of significant value in advanced pharmaceutical research and development, particularly for its potential role in modulating enzymatic pathways and cellular signaling. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including antiviral agents, oncology treatments, and metabolic disorder drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleotide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and signal transduction mechanisms.
• Antiviral Drug Development: Investigated for its potential incorporation into prodrugs targeting viral polymerases due to its modified nucleoside structure.
• Oncology Research: Explored for its ability to interfere with DNA/RNA synthesis in rapidly dividing cells, making it a candidate for anticancer agent development.
• Proteomics & Molecular Biology: Utilized in the study of protein-nucleic acid interactions and the development of labeled probes for diagnostic assays.
• Preclinical Studies: Employed in in vitro and in vivo models to assess pharmacokinetics, pharmacodynamics, and initial efficacy of new therapeutic candidates.

Basic Information

Item	Details
Product Name	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-(3-hydroxypropanoylsulfanyl)ethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
CAS No.	157786-88-4
Molecular Formula	C24H41N8O18P3S
Molecular Weight	878.62 g/mol
Synonyms	Adenosine triphosphate analog; Modified ATP derivative; Nucleotide prodrug intermediate; 5'-O-[{Hydroxy(3-hydroxy-3-{2-[2-(3-mercaptopropionamido)ethylcarbamoyl]ethylcarbamoyl)-2,2-dimethylpropoxy)phosphoryl]oxyphosphoryl}adenosine derivative; Custom nucleotide; Research-grade nucleotide analog; Phosphorylated nucleoside conjugate
EINECS	Contact for details

Quality Control

Our production of this high-purity nucleotide analog adheres to stringent quality protocols. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to confirm identity, purity, and structural integrity. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research and development requirements. Quality management is supported by a system aligned with cGMP principles where applicable for non-clinical material production.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); containers should be allowed to equilibrate to room temperature before opening to minimize condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.