Description

2-Butanol, 4-[1-[4-[[3,5-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methylenecyclohexylidene]ethylidene]octahydro-7a-Methyl-1H-inden-1-yl]ethoxy]-2-Methyl-, [1S-[1α(R*),3aβ,4E(1Z,3R*,5S*),7aα]]- (9CI) is a highly specialized, sterically hindered organosilicon-protected intermediate of significant value in advanced organic synthesis. Its complex molecular architecture, featuring tert-butyldimethylsilyl (TBDMS) protecting groups, makes it a critical building block for constructing intricate, chiral frameworks. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries who require high-purity, advanced intermediates for complex molecule assembly.

Application

• Advanced Pharmaceutical Intermediates: Serves as a key chiral synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly for steroids and other polycyclic systems.
• Fine Chemical Synthesis: Used in the research and development of novel organic compounds requiring precise stereochemistry and protected functional groups.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of high-value target molecules in pilot plants and kilo-labs.
• Academic and Industrial Research: A valuable tool for chemists exploring new synthetic methodologies, total synthesis of natural products, and material science.
• Chiral Auxiliary and Ligand Precursor: The defined stereocenters can be leveraged in the development of chiral catalysts or auxiliaries for asymmetric synthesis.

Basic Information

Item	Detail
Product Name	2-Butanol, 4-[1-[4-[[3,5-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methylenecyclohexylidene]ethylidene]octahydro-7a-Methyl-1H-inden-1-yl]ethoxy]-2-Methyl-, [1S-[1α(R*),3aβ,4E(1Z,3R*,5S*),7aα]]- (9CI)
CAS No.	152517-44-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	9CI-152517-44-7; (1S,3aR,5S,7aS,9R,11aR,11bS)-5-[(2R)-1-[(1S,3aR,4E,7aS)-4-[(1Z)-1-[(3,5-Bis[[tert-butyl(dimethyl)silyl]oxy]-2-methylidenecyclohexylidene)ethylidene]-7a-methyl-octahydro-1H-inden-1-yl]ethoxy]-2-methyl-butyl]-1,2,3,3a,5,6,7,7a,8,9,10,11a,11b,11c-tetradecahydro-9,11a-dimethyl-cyclopenta[a]phenanthren-3a-ol; Steroid TBDMS-protected intermediate; Chiral polycyclic silyl ether.
EINECS	Contact for details

Quality Control

Our 2-Butanol, 4-[1-[4-[[3,5-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methylenecyclohexylidene]ethylidene]octahydro-7a-Methyl-1H-inden-1-yl]ethoxy]-2-Methyl-, [1S-[1α(R*),3aβ,4E(1Z,3R*,5S*),7aα]]- (9CI) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and identity confirmation, to ensure it meets the exacting standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.