Description

S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-tetradec-11-enethioate is a sophisticated, high-purity nucleotide-lipid conjugate designed for advanced research and development applications. This compound is critical for targeted drug delivery systems, particularly in the formulation of lipid nanoparticles (LNPs) for mRNA and other nucleic acid therapeutics. It is primarily utilized by pharmaceutical R&D teams and biotech companies focused on next-generation genetic medicines and vaccine platforms.

Application

• Ionizable Lipid Component for Lipid Nanoparticles (LNPs): A key functional excipient for encapsulating and delivering mRNA, siRNA, and other nucleic acid payloads.
• Advanced Drug Delivery Research: Used in the development of targeted therapeutic systems for oncology, genetic disorders, and infectious diseases.
• Vaccine Platform Development: Essential for formulating novel mRNA-based vaccines, enabling efficient cellular uptake and endosomal escape.
• Gene Therapy Formulations: A critical material for non-viral vector systems designed for gene editing and protein replacement therapies.
• Bioconjugation and Prodrug Synthesis: Serves as a specialized intermediate for creating nucleotide-targeted prodrugs and diagnostic agents.
• Biomedical Research & Diagnostics: Used in academic and industrial labs to study intracellular delivery mechanisms and cell membrane interactions.

Basic Information

Item	Details
Product Name	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-tetradec-11-enethioate
CAS No.	150883-39-9
Molecular Formula	C₃₉H₆₈N₇O₁₇P₃S
Molecular Weight	1040.0 g/mol (approx.)
Synonyms	Nucleotide-Lipid Conjugate; Adenosine Monophosphate Lipid Ester; AMP-C14 Lipid; (Z)-11-Tetradecenyl Thioate Adenosine Derivative; Ionizable Cationic Lipid Intermediate; 5'-AMP Lipid Prodrug; S-(2-(3-((R)-4-((((((2R,3R,5R)-5-(6-Aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl)methoxy(hydroxy)phosphoryl)oxy(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanamido)propanamido)ethyl) (Z)-tetradec-11-enethioate
EINECS	Contact for details

Quality Control

Our S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-tetradec-11-enethioate is manufactured under strict quality management systems to ensure batch-to-batch consistency for critical pharmaceutical development. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.